Rooted in the period of Pop-Art, Op-art and Nouveau Realisme, Van Hoeydonck managed to devise a completely new oeuvre with his Space-Art. Throughout his career, Van Hoeydonck stood aside dominating styles and movements and in over 50 years of activity the concern of manhood and its interaction with the space it occupies had been central to his work. In 1971, in cooperation with the Wadell Gallery in New York, a sculpture made by Van Hoeydonck was taken by the Apollo 15 crew and placed on the moon.
Whitford Fine Art is the leading gallery in the UK to represent the work by Paul Van Hoeydonck. In 1990 the gallery held a one-man show titled Paintings and Collages 1955 - 1959 in which it exhibited the artist's works from the Fifties.