Cutrone worked as an assistant of Andy Warhol from 1972 until 1980, when his place was taken by Shriver so that Cutrone could concentrate on his own painting. Together with Kenny Sharf, he revived the comic strip in painting.
By using established comic characters such as Woody Woodpecker and Felix the Cat, Cutrone rephrased themes of originality and authorship, and of low-brow taste and fine art which makes him directly indebted to Pop Art of early Sixties.
His use of bright and fluorescent colours encouraged Andy Warhol's return to such hues of heightened artificiality. Cutrone's work has been exhibited in America and Europe.